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Common side effects include nausea and digestive discomfort

In a 2022 review of 21 placebo-controlled randomized trials that tested a broad swath of purported hangover-prevention ingredients, researchers concluded only very low quality evidence of efficacy is available to recommend any pharmacologically active intervention for the treatment or prevention of alcohol-induced hangover. What causes hangoversand can these products really do anything about it

Bauchat JR, Busby WH Jr, Garmong A, Swanson P, Moore J, Lin M, Duan C (2001) Biochemical and functional analysis of a conserved IGF-binding protein isolated from rainbow trout ( Oncorhynchus mykiss ) hepatoma cells

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